Fluorometric assay for N-acetylprocainamide.
نویسندگان
چکیده
We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective lenear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 +/- 3.0% and 98.0 +/- 4.0%, respectively. For determination of either compound, the maximum coefficient of variation was 10%.
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procainamide and N-acetylprocainamide in plasma or serum by high-performance liquid chromatography. Clin Chem 197723:7058. 10. Lai C, Kaniath BL, Look ZM, Yacobi A. Determination of procainamide and N-acetylprocainamide in biological fluids by high-pressure liquid chromatography. J Pharm Sci 1980;69:982-4. 11. Walberg CB, Wan SH. Clinical evaluation of EMIT procainamide and N-acetylprocainainid...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 21 13 شماره
صفحات -
تاریخ انتشار 1975